商品编号


F8141



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

25 mg

商品信息

AZD6738 is a potent inhibitor of ATR kinase. It potentiates the cytotoxicity of cisplatin and gemcit
ABI
ne in non-small cell lung cancer (NSCLC) cell lines with intact ATM kinase signaling, and potently synergizes with cisplatin in ATM-deficient NSCLC cells.


Additional Information






Product Name:

AZD6738



Also Known As:

4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine



Catalog No.:

F8141



Size:

25 mg



CAS:

1352226-88-0



Formula:

C
20
H
24
N
6
O
2
S



Molecular Weight:

412.51 Da



Form:

Lyophilized powder



Quality Assurance:

>98% by HPLC and NMR



Source:

Synthetic



Storage:

Elig
IBL
e for room temperature shipping. Store at -80°C upon receiving



PDF Data Sheet:

Download PDF datasheet



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

Vendetti FP,
et al
. (2015) Oncotarget. Oct 27.




Details

AZD6738 is a potent inhibitor of ATR kinase. It potentiates the cytotoxicity of cisplatin and gemcit
ABI
ne in non-small cell lung cancer (NSCLC) cell lines with intact ATM kinase signaling, and potently synergizes with cisplatin in ATM-deficient NSCLC cells.

Solubility:

20 mg/ml in DMSO