商品编号


F8100



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

5 mg

商品信息

Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL. Idarubicin is developed in an attempt to reduce the cardiotoxicity and enhance the therapeutic efficacy of the parent compound. Idarubicin HCl is an inhibitor of Topo II α and an apoptosis inducer. Idarubicin HCL was used at 0.1 nM - 10 nM in various cell-based in vitro assays.


Additional Information






Product Name:

Idarubicin HCl



Also Known As:

4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl



Catalog No.:

F8100



Size:

5 mg



Molecular Weight:

533.95 Da



Species:

N/A



Source:

Synthetic



Stock:

Powder



Concentration:

N/A



Quality Assurance:

>99% by HPLC and NMR



Storage:

Elig
IBL
e for room temperature shipping. Store at -20°C upon receiving; protect from air and light



PDF Data Sheet:

PDF Datasheet



NCBI RefSeq:

N/A



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

1. Fukushima T,
et al
. (1993). Int. J. Hematol. 57: 121-130.
2. Belaud-Rotureau MA,
et al
. (2000). Leukemia. 14: 1266-1275.
3. Orlandi P,
et al
. (2005) J Chemother. 17(6): 663-667.
4. Colburn DE,
et al
. (2004) Hematology. 9(3): 217-221.




Details

Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL. Idarubicin is developed in an attempt to reduce the cardiotoxicity and enhance the therapeutic efficacy of the parent compound. Idarubicin HCl is an inhibitor of Topo II α and an apoptosis inducer.

How to use
Idarubicin HCL was used at 0.1 nM - 10 nM in various cell-based in vitro assays.