商品编号


F7160



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

5 mg

商品信息

Pifithrin-alpha is an inhibitor of p53, revers
IBL
y inhibits p53-dependent transactivation of p53-responsive genes and apoptosis. Pifithrin-α (10 μM) enhances cell survival after genotoxic stress such as UV irr
ADI
ation and treatment with DNA damage compounds including doxorubicin, etopoxide, and paclitaxel.


Additional Information






Product Name:

Pifithrin-alpha



Also Known As:

Pifithrin-α, Ethanone, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-, hydrobromide (1:1)



Catalog No.:

F7160



Size:

5 mg



CAS:

63208-82-2



Formula:

C
16
H
18
N
2
OS.HBr



Molecular Weight:

367.3 Da



Form:

Lyophilized powder



Quality Assurance:

>98% by HPLC and NMR



Source:

Synthetic



Storage:

Elig
IBL
e for room temperature shipping. Store at -80°C upon receiving



PDF Data Sheet:

Download PDF datasheet



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

Komarov, PG,
et al
. (1999) Science 285, 1733-1737




Details

Pifithrin-alpha is an inhibitor of p53, revers
IBL
y inhibits p53-dependent transactivation of p53-responsive genes and apoptosis. Pifithrin-α (10 μM) enhances cell survival after genotoxic stress such as UV irr
ADI
ation and treatment with DNA damage compounds including doxorubicin, etopoxide, and paclitaxel.

Solubility:

20 mg/ml in DMSO

Working Condition:

10 μM