商品编号


F6165-25



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

25 mg

商品信息

ONC201 (also called TIC10) is a potent TRAIL inducer by inhibition of ERK and AKT. ONC201 promotes nuclear localization of Foxo3a, which then enhances TRAIL transcription to induce cancer cell death. ONC201 is orally active.

Additional Information






Product Name:

ONC201 (TIC10)



Also Known As:

CAS# 41276-02-2



Catalog No.:

F6165-25



Size:

25 mg



Molecular Weight:

386.49 Da



Species:

N/A



Source:

Synthetic



Stock:

Powder



Concentration:

N/A



Quality Assurance:

>98% by HPLC and NMR



Storage:

Elig
IBL
e for room temperature shipping. Store at -80°C upon receiving; avoid multiple freeze-thaw cycles after dissolving in DMSO.



PDF Data Sheet:

Download PDF datasheet



NCBI RefSeq:

N/A



Image(s):

No



Shipping Method:

Room temperature shipping



References:

1. Allen J E,
et al
. (2013) Sci. Transl. Med., 5, 171ra17
2. Kline C,
et al
. (2016) Sci. Signal ., 9, 18r




Details

ONC201 (also called TIC10) is a potent TRAIL inducer by inhibition of ERK and AKT. ONC201 promotes nuclear localization of Foxo3a, which then enhances TRAIL transcription to induce cancer cell death. ONC201 is orally active.