商品编号


F4110



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

5 mg


商品信息

P5091 is a cell permeable, selective and potent inhibitor of ubiquitin-specific protease 7 (
USP
7, IC?? = 4.2 ?M) and
USP
47. P5091(P005091) induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. It inhibits tumor growth in animal models of cancer.

Additional Information






Product Name:

P5091



Also Known As:

1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone



Catalog No.:

F4110



Size:

5 mg



Molecular Weight:

348.22 Da



Species:

N/A



Source:

Synthetic



Stock:

Powder



Concentration:

N/A



Quality Assurance:

>99% by HPLC and NMR



Storage:

Elig
IBL
e for room temperature shipping. Store at -20°C upon receiving; protect from air and light



PDF Data Sheet:

PDF Datasheet



NCBI RefSeq:

N/A



Image(s):

(Click image to enlarge)

Purity check of P5091 by HPLC



Shipping Method:

Room temperature shipping



References:

1. Jeffrey GM,
et al
. (2009) IDrugs. 12(12):750–753.
2. Chauhan D,
et al
. (2012) Cancer Cell 22(3): 345-358.




Details

P5091 is a cell permeable, selective and potent inhibitor of ubiquitin-specific protease 7 (
USP
7, IC?? = 4.2 ?M) and
USP
47. P5091(P005091) induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. It inhibits tumor growth in animal models of cancer.

How to use
In vitro: P5091 was used at 5-12 ?M in various in vitro assays
In vivo: P5091 was admi
NIST
ered through IV injection at 10 mg/kg twice weekly for 3 weeks.
Images
(Click image to enlarge)

Purity check of P5091 by HPLC