商品编号


F2120



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

5 mg

商品信息

WP-1130 is a partial selective inhibitor of DUBs including
USP
9x,
USP
5,
USP
14, UchL1 and Uch37. WP-1130 treatment was found to suppress the Jak-Stat signaling pathway, induce aggresome formation and lead to tumor cell apoptosis.
Typical concentration for cell culture experiments is 1-5?M.


Additional Information






Product Name:

WP-1130



Also Known As:

Degrasyn; (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide; CAS# 856243-80-6; C19H18BrN3O



Catalog No.:

F2120



Size:

5 mg



Molecular Weight:

384.3 Da



Species:

N/A



Source:

Synthetic



Stock:

Powder



Concentration:

N/A



Quality Assurance:

> 98% (TLC); NMR (Confirms)



Storage:

Elig
IBL
e for room temperature shipping. Store at -20°C upon receiving; protect from air and light



PDF Data Sheet:

PDF Datasheet



NCBI RefSeq:

N/A



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

1. Kapuria V
et al
. (2010) Cancer Res. 70(22):9265-76.
2. Bartholomeusz GA
et al
. (2007) Blood. 109(8):3470-8.




Details

WP-1130 is a partial selective inhibitor of DUBs including
USP
9x,
USP
5,
USP
14, UchL1 and Uch37. WP-1130 treatment was found to suppress the Jak-Stat signaling pathway, induce aggresome formation and lead to tumor cell apoptosis. Typical concentration for cell culture experiments is 1-5?M.