商品编号


F2111



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

50 mg

商品信息

A cell-permeable pan deubiquitinating enzyme inhibitor that is known to inhibit ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37,
USP
1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. PR-619 inhibits many deubiquitinating enzymes in the 5-20?M range. Treating cells with PR-619 results in the accumulation of both ubiquitin and sumo-conjugated proteins.


Additional Information






Product Name:

PR-619



Also Known As:

(2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate; CAS# 2645-32-1; C7H5N5S2



Catalog No.:

F2111



Size:

50 mg



Molecular Weight:

223.28 Da



Species:

N/A



Source:

Synthetic



Stock:

Powder



Concentration:

N/A



Quality Assurance:

≥ 98% by HPLC



Storage:

Elig
IBL
e for room temperature shipping. Store at -20°C upon receiving; protect from air and light



PDF Data Sheet:

PDF Datasheet



NCBI RefSeq:

N/A



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

1. Tian X.,
et al
. (2011) Assay Drug Dev Technol. 9(2):165-73.
2. Seiberlich V.,
et al
. (2012) Biochim Biophys Acta. 1823(11):2057-68.




Details

A cell-permeable pan deubiquitinating enzyme inhibitor that is known to inhibit ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37,
USP
1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. PR-619 inhibits many deubiquitinating enzymes in the 5-20?M range. Treating cells with PR-619 results in the accumulation of both ubiquitin and sumo-conjugated proteins.