商品编号


F2101



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

10 mg

商品信息

b-AP15 is a specific inhibitor of the deubiquitinating enzymes Uch37 and
USP
14 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. Treating cells with b-AP15 causes the accumulation of polyubiquitinated proteins, inhibition of proteasomal degradation, upregulation of apoptotic
Marker
s and cell death.

Additional Information






Product Name:

b-AP15



Also Known As:

No



Catalog No.:

F2101



Size:

10 mg



Molecular Weight:

419.4 Da



Species:

N/A



Source:

Synthetic



Stock:

Powder



Concentration:

N/A



Quality Assurance:

>98% by HPLC and NMR



Storage:

Elig
IBL
e for room temperature shipping. Store at -80°C upon receiving; avoid multiple freeze-thaw cycles after dissolving in DMSO.



PDF Data Sheet:

Download PDF datasheet



NCBI RefSeq:

N/A



Image(s):

No



Shipping Method:

Room temperature shipping



References:

1. D’Acry P,
et al
. (2011) Nat. Med. 17. 1636.




Details

b-AP15 is a specific inhibitor of the deubiquitinating enzymes Uch37 and
USP
14 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. Treating cells with b-AP15 causes the accumulation of polyubiquitinated proteins, inhibition of proteasomal degradation, upregulation of apoptotic
Marker
s and cell death.

Images
(Click image to enlarge)

Equal amount of whole cell lysates prepared from DMSO (lane 1) or 2 μM b-AP15 (lane 2)-treated HeLa cells were separated by SDS-PAGE and immunoblotted with an anti-Ub antibody. HEK293TCells were treated with DMSO or b-AP15 for 5 hours.