商品编号


H5710



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Deubiquitinating Enzymes



Size

25 ?g

商品信息

USP
7 is a cysteine protease, belongs to the family of ubiquitin-specific proteases.
USP
7 was first discovered as a binding enzyme to the Herpes simplex viral protein. Studies have shown that
USP
7 could deubiquitinate the autoubiquitination of an E3
ligase called HDM2 that promotes ubiquitination and subsequent degradation of p53. The
USP
7/HDM2/p53 interaction results in higher protein levels of HDM2 and lower levels of p53. Because of its apparent role in different types of pathologies, including lung and liver cancer, it has become a poss
IBL
e target for drug therapies.

Additional Information






Product Name:

GST-
USP
7



Also Known As:

TEF1; HA
USP



Catalog No.:

H5710



Size:

25 ?g



Molecular Weight:

128.3 kDa



Species:

Human



Source:

Sf9 insect cells



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~90% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_003470



Image(s):

N/A



Shipping Method:

Dry ice shipping



References:

1. Everett RD,
et al
. (1997) EMBO J 16(7), 1519 – 1530.
2. Li M,
et al
. (2004) Mol Cell 26(13), 879 – 886. 3. Cummins JM,
et al
(2004) Nature 428(6982), 1 p following 486.
4. Nicholson B,
et al
. (2011) Cell Biochem Biophys 60(1 – 2), 61 – 68.




Details


USP
7 is a cysteine protease, belongs to the family of ubiquitin-specific proteases.
USP
7 was first discovered as a binding enzyme to the Herpes simplex viral protein. Studies have shown that
USP
7 could deubiquitinate the autoubiquitination of an E3 ligase called HDM2 that promotes ubiquitination and subsequent degradation of p53. The
USP
7/HDM2/p53 interaction results in higher protein levels of HDM2 and lower levels of p53. Because of its apparent role in different types of pathologies, including lung and liver cancer, it has become a poss
IBL
e target for drug therapies.