商品编号


H5410



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Deubiquitinating Enzymes



Size

50 ?g


商品信息

USP
4 is a member of the ubiquitin-specific protease family of deubiquitinating enzyme. A number of substrates of
USP
4 have been identified, including TRIM21, TRAF2, TRAF6, RIG-1, RIP1, PDK1, TAK1 and etc.
USP
4-mediated deubiquitination was found to regulate several signaling pathways, including the AKT signaling, RIG-1-mediated antiviral response, TNFα-induced signaling, and the Wnt signaling.

Additional Information






Product Name:

GST-
USP
4



Also Known As:

UNP; Unph



Catalog No.:

H5410



Size:

50 ?g



Molecular Weight:

108.6 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~ 75% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_003363.3



Image(s):


Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified GST-
USP
4







Shipping Method:

Dry ice shipping



References:

1. Wang L,
et al
. (2013) J Virol. 87(8):4507-15.
2. Zhang L,
et al
. (2012) Nat Cell Biol. 14(7):717-26.
3. Xiao N,
et al
. (2012) Biochem J. 441(3):979-86.




Details


USP
4 is a member of the ubiquitin-specific protease family of deubiquitinating enzyme. A number of substrates of
USP
4 have been identified, including TRIM21, TRAF2, TRAF6, RIG-1, RIP1, PDK1, TAK1 and etc.
USP
4-mediated deubiquitination was found to regulate several signaling pathways, including the AKT signaling, RIG-1-mediated antiviral response, TNFα-induced signaling, and the Wnt signaling.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified GST-
USP
4