商品编号


H4020



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Deubiquitinating Enzymes



Size

50 ?g


商品信息

OTULIN is a deubiquitinating enzyme that specifically cleaves linear polyubiquitin chains. It associates with the LUBAC ubiquitin ligase complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains. OTULIN functions as a regulator of angiogenesis and innate immune response.

Additional Information






Product Name:

6xHis-OTULIN



Also Known As:

GUM; FAM105B



Catalog No.:

H4020



Size:

50 ?g



Molecular Weight:

40.3 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~ 90% by SDS-PAGE



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_032663.4



Image(s):

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-OTULIN







Shipping Method:

Dry ice shipping



References:

1. Tzvetkov N,
et al
. (2007) Biol. Chem. 388:973-978
2. Li F,
et al
. (2002) J. Biol. Chem. 277:45004-45012
3. Winborn BJ,
et al
. (2008) J Biol Chem. 26;283(39):26436-43




Details

OTULIN is a deubiquitinating enzyme that specifically cleaves linear polyubiquitin chains. It associates with the LUBAC ubiquitin ligase complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains. OTULIN functions as a regulator of angiogenesis and innate immune response.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-OTULIN