商品编号


H3000



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Deubiquitinating Enzymes



Size

25 ?g

商品信息

Deubiquitinating enzymes (DUBs) are proteases that posses the
ABI
lity to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. OTUB1 is a member of the ovarian tumor domain family. It is recognized as a K48 ubiquitin chain-specific DUB and can inhibit E2 enzymes, especially Ubc13 (also known as Ube2N), which is known to synthesize K63-linked ubiquitin chains. OTUB1 may also deubiquitinate TRAF3 and -6. This would negatively regulate virus-triggered type I IFN induction.

Additional Information






Product Name:

OTUB1



Also Known As:

OTB1; OTU1; HSPC263



Catalog No.:

H3000



Size:

25 ?g



Molecular Weight:

31.2 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~95% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_017670



Image(s):

N/A



Shipping Method:

Dry ice shipping



References:

1. Balakirev MY,
et al.
(2003) EMBO Rep 4(5), 517 – 522.
2. Wang T,
et al.
(2009) J Mol Biol 386(4), 1011 – 1023. 3. Reyes-Turcu FE,
et al.
(2009) Annu Rev Biochem 78, 363 – 397.
4. Li S,
et al.
(2010) J Biol Chem 285(7), 4291 – 4297. 5. Wiener R,
et al.
(2012) Nature 483(7391), 618 – 622.




Details

Deubiquitinating enzymes (DUBs) are proteases that posses the
ABI
lity to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. OTUB1 is a member of the ovarian tumor domain family. It is recognized as a K48 ubiquitin chain-specific DUB and can inhibit E2 enzymes, especially Ubc13 (also known as Ube2N), which is known to synthesize K63-linked ubiquitin chains. OTUB1 may also deubiquitinate TRAF3 and -6. This would negatively regulate virus-triggered type I IFN induction.