商品编号


C4001



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


E2 Conjugating Enzymes



Size

100 ?g


商品信息

Ube2W is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. It has been shown to catalyze monoubiquitination of Fanconi anemia complementation group L (FANCL), an E3 Ub ligase. The FANCL is part of a complex that is able to monoubiquitinate FANCD2 during DNA repair. Ube2W can also interact with the RING domain of the breast and ovarian cancer susceptibility protein called BRCA1.

Additional Information






Product Name:

6xHis-Ube2W



Also Known As:

UBC16; UBC-16; hUBC-16; FLJ11011



Catalog No.:

C4001



Size:

100 ?g



Molecular Weight:

18.7 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~90% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_001001481



Image(s):

(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2W







Shipping Method:

Dry ice shipping



References:

1. Yin G,
et al
. (2006) Front Biosci 11, 1500 – 1507.
2. Christensen DE,
et al
. (2007) Nat Struct Mol Biol 14, 941 – 948. 3. Alpi AF,
et al
. (2008) Mol Cell 32, 767 – 777.
4. Zhang Y,
et al
. (2011) Mol Cells 31(2), 113 – 122.




Details

Ube2W is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. It has been shown to catalyze monoubiquitination of Fanconi anemia complementation group L (FANCL), an E3 Ub ligase. The FANCL is part of a complex that is able to monoubiquitinate FANCD2 during DNA repair. Ube2W can also interact with the RING domain of the breast and ovarian cancer susceptibility protein called BRCA1.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2W