商品编号


C4000



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


E2 Conjugating Enzymes



Size

25 ?g


商品信息

Ube2W is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. It has been shown to catalyze monoubiquitination of Fanconi anemia complementation group L (FANCL), an E3 Ub ligase. The FANCL is part of a complex that is able to monoubiquitinate FANCD2 during DNA repair. Ube2W can also interact with the RING domain of the breast and ovarian cancer susceptibility protein called BRCA1.UBC16; UBC-16; hUBC-16; FLJ11011

Additional Information






Product Name:

6xHis-Ube2W



Also Known As:

UBC16; UBC-16; hUBC-16; FLJ11011



Catalog No.:

C4000



Size:

25 ?g



Molecular Weight:

18.7 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~90% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_001001481



Image(s):

(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2W







Shipping Method:

Dry ice shipping



References:

1. Yin G,
et al
. (2006) Front Biosci 11, 1500 – 1507.
2. Christensen DE,
et al
. (2007) Nat Struct Mol Biol 14, 941 – 948. 3. Alpi AF,
et al
. (2008) Mol Cell 32, 767 – 777.
4. Zhang Y,
et al
. (2011) Mol Cells 31(2), 113 – 122.




Details

Ube2W is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. It has been shown to catalyze monoubiquitination of Fanconi anemia complementation group L (FANCL), an E3 Ub ligase. The FANCL is part of a complex that is able to monoubiquitinate FANCD2 during DNA repair. Ube2W can also interact with the RING domain of the breast and ovarian cancer susceptibility protein called BRCA1.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2W