商品编号


4336-BPC-100



品牌


Trevigen



公司


Trevigen, Inc



公司分类


DNA Damage



Size

100 μl

商品信息

Description

ANTIBODY CONCENTRATION
Provided in 1X PBS containing 50% glycerol.
This rabbit polyclonal antibody is a purified IgG fraction.

IMMUNOGEN
Poly(ADP-ribose) polymer

SPECIFICITY
This antibody detects free PAR and poly-ribosylated proteins.

STORAGE
Store antibody at -20°C in a manual defrost freezer.

APPLICATIONS

ELISA
and Western Blot Analysis

Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib
Murai, J., Huang, S.N., Renaud, A., Zhang, Y., Ji, J., Takeda, S., Morris, J., Teicher, B., Doroshow, J.H., and Pommier, Y., Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib41671Molecular Cancer Therapeutics
Mol. Cancer Ther., Feb 2014; 13: 433 – 443
http://mct.aacrjournals.org/cgi/content/abstract/13/2/433

Nitric Oxide Induces Ataxia Telangiectasia Mutated ATM Protein-dependent gammaH2AX Protein Formation in Pancreatic beta Cells,
Bryndon J. Oleson, Katarzyna A. Broniowska, Katherine H. Schreiber, Vera L. Tarakanova, and John A. Corbett
J. Biol. Chem., Apr 2014; 289: 11454 – 11464
http://www.jbc.org/cgi/content/abstract/289/16/11454

ABCB1, ABCG2, and PTEN Determine the Response of Glioblastoma to Temozolomide and ABT-888 Therapy
Lin, F., de Gooijer, M.C., Roig, E.M., Buil, L.C.M., Christner, S.M., Beumer, J.H., Wurdinger, T., Beijnen, J.H. and van Tellingen, O.
Clin. Cancer Res., May 2014; 20: 2703 – 2713.
http://clincancerres.aacrjournals.org/cgi/content/abstract/20/10/2703

Rationale for Poly(ADP-ribose) Polymerase (PARP) Inhibitors in Combination Therapy with Camptothecins or Temozolomide Based on PARP Trapping versus Catalytic Inhibition
Murai, J., Zhang, Y., Morris, J., Ji, J., Takeda, S., Doroshow, J.H. and Pommier, Y.
J. Pharmacol. Exp. Ther., May 2014; 349: 408 – 416.
http://jpet.aspetjournals.org/cgi/content/abstract/349/3/408

PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress
Giuditta Illuzzi, Elise Fouquerel, Jean-Christophe Amé, Aurélia Noll, Kristina Rehmet, Heinz-Peter Nasheuer, Fran?oise Dantzer, and Valérie Schreiber
Nucleic Acids Res., Aug 2014; 42: 7776 – 7792
http://nar.oxfordjournals.org/cgi/content/abstract/42/12/7776

Hyperthermia Inhibits Recombination Repair of Gemcit
ABI
ne-Stalled Replication Forks
Mustafa Raoof, Cihui Zhu, Brandon T. Cisneros, Heping Liu, Stuart J. Corr, Lon J. Wilson, and Steven A. Curley
J Natl Cancer Inst, Aug 2014; 106: dju183
http://jnci.oxfordjournals.org/cgi/content/abstract/106/8/dju183

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
Marie-France Langelier, Amanda A. Riccio, and John M. Pascal
Nucleic Acids Res., Aug 2014; 42: 7762 – 7775.
http://nar.oxfordjournals.org/cgi/content/abstract/42/12/7762

Regulation of Mitochondrial Poly(ADP-Ribose) Polymerase Activation by the β-Adrenoceptor/cAMP/Protein Kinase A Axis during Oxidative Stress
Attila Brunyanszki, Gabor Olah, Ciro Coletta, Bartosz Szczesny, and Csaba Szabo
Mol. Pharmacol., Sep 2014; 86: 450 – 462.
http://molpharm.aspetjournals.org/cgi/content/abstract/86/4/450

PARP-1 Mediates LPS-Induced HMGB1 Release by Macrophages through Regulation of HMGB1 Acetylation
Zhiyong Yang, Li Li, Lijuan Chen, Weiwei Yuan, Liming Dong, Yushun Zhang, Heshui Wu, and Chunyou Wang
J. Immunol., Dec 2014; 193: 6114 – 6123
http://www.jimmunol.org/cgi/content/abstract/193/12/6114

“Femtosecond near-infrared laser microirr
ADI
ation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites”
Gladys Mae Saquilabon Cruz, Xiangduo Kong, Bárbara Alcaraz Silva, Nima Khatibzadeh, Ryan Thai, Michael W. Berns, and Kyoko Yokomori
Nucleic Acids Res., Sep 2015; 10.1093/nar/gkv976.
http://nar.oxfordjournals.org/content/early/2015/09/30/nar.gkv976.full

The PIN domain of EXO1 recognizes poly(ADP-ribose) in DNA damage response
Feng Zhang, Jiazhong Shi, Shih-Hsun Chen, Chunjing Bian, and Xiaochun Yu
Nucleic Acids Res., Dec 2015; 43: 10782 – 10794.
http://nar.oxfordjournals.org/cgi/content/abstract/43/22/10782

Femtosecond near-infrared laser microirr
ADI
ation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites
Gladys Mae Saquilabon Cruz, Xiangduo Kong, Bárbara Alcaraz Silva, Nima Khatibzadeh, Ryan Thai, Michael W. Berns, and Kyoko Yokomori
Nucleic Acids Res., Feb 2016; 44: e27
http://nar.oxfordjournals.org/cgi/content/abstract/44/3/e27

“A R
ADI
otracer Strategy to Quantify PARP-1 Expression In Vivo
Provides a Bio
Marker
That Can Enable Patient Selection foPARP
Inhibitor Therapy”
“Mehran Makvandi, Kuiying Xu, Brian P. Lieberman, Redmond-Craig Anderson, Samuel Sander Effron,
Harrison D. Winters, Chenbo Zeng, Elizabeth S. McDonald, Daniel A. Pryma, Roger A. Greenberg, and
Robert H. Mach”
Cancer Res., Aug 2016; 76: 4516 – 4524
http://cancerres.aacrjournals.org/cgi/content/abstract/76/15/4516

Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells
Subhendu K. Das, Ishita Rehman, Arijit Ghosh, Souvik Sengupta, Papiya Majumdar, Biman Jana, and Benu Brata Das
Nucleic Acids Res., Sep 2016; 44: 8363 – 8375.
http://nar.oxfordjournals.org/cgi/content/abstract/44/17/8363

The role of ADP-ribosylation in regulating DNA interstrand crosslink repair
Alasdair R. Gunn, Benito Banos-Pinero, Peggy Paschke, Luis Sanchez-Pulido, Antonio Ariza, Joseph Day, Mehera Emrich, David Leys, Chris P. Ponting, Ivan Ahel, and Nicholas D. Lakin
J. Cell Sci., Oct 2016; 129: 3845 – 3858
http://jcs.
BIOLOG
ists.org/cgi/content/abstract/129/20/3845