商品编号


C3701



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


E2 Conjugating Enzymes



Size

100 ?g


商品信息

Ube2S is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. Ube2S works with a Ub ligase, anaphase-promoting complex (APC/C), to ubiquitinate proteins like Cyclin B1 to be degraded by the 26S proteasome. Ube2S was found to produce K11-specific Ub chains.

Additional Information






Product Name:

6xHis-Ube2S



Also Known As:

EPF5; E2EPF; E2-EPF



Catalog No.:

C3701



Size:

100 ?g



Molecular Weight:

23.8 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~90% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_014501



Image(s):

(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2S







Shipping Method:

Dry ice shipping



References:

1. Liu Z,
et al
. (1992) J Biol Chem 267(22), 15829 – 15835.
2. Garnett MJ,
et al
. (2009) Nat Cell Biol 11, 1363 – 1369. 3. Williamson A,
et al
. (2009) Proc Natl Acad Sci USA 106, 18213 – 18218.
4. Wu T,
et al
. (2010) Proc Natl Acad Sci USA 107(4), 1355 – 1360.




Details

Ube2S is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. Ube2S works with a Ub ligase, anaphase-promoting complex (APC/C), to ubiquitinate proteins like Cyclin B1 to be degraded by the 26S proteasome. Ube2S was found to produce K11-specific Ub chains.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2S