商品编号


C3601



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


E2 Conjugating Enzymes



Size

100 ?g


商品信息

Ube2R2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. Ube2R2 is phosphorylated by CK2 before it can bind to SCF (Skp1, Cul1, F-box) subunit β-
TRC
P. This E2 catalyzes K48 – linked Ub chains, which when conjugated to substrates, are targeted to the 26S proteasome for degradation.

Additional Information






Product Name:

6xHis-Ube2R2



Also Known As:

UBC3B; CDC34B; E2-CDC34B; FLJ20419; MGC10481



Catalog No.:

C3601



Size:

100 ?g



Molecular Weight:

27.2 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~90% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_017811



Image(s):

(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2R2







Shipping Method:

Dry ice shipping



References:

1. Semplici F,
et al
. (2002) Oncogene 21, 3978 – 3987.
2. Jin J,
et al
. (2007) Nature 447(7148), 1135 – 1138. 3. David Y,
et al
. (2010) J Biol Chem 285(12), 8595 – 8604.




Details

Ube2R2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. Ube2R2 is phosphorylated by CK2 before it can bind to SCF (Skp1, Cul1, F-box) subunit β-
TRC
P. This E2 catalyzes K48 – linked Ub chains, which when conjugated to substrates, are targeted to the 26S proteasome for degradation.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2R2