商品编号


C1800



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


E2 Conjugating Enzymes



Size

25 ?g


商品信息

Ube2E1 is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. Ube2E1 was found to locate in the nucleus. It, along with Ube2D1, is known to complex with the E3 ligase Ro52 to ubiquitinate interferon regulatory transcription factors IRF3 and IRF8. Ube2E1 can also complex with a Ub ligase called RING105 to ubiquitinate a tumor suppressor known as tumor – suppressing subchromosomal transferable fragment
CDN
A (TSSC5).

Additional Information






Product Name:

6xHis-Ube2E1 (UbcH6)



Also Known As:

UBCH6



Catalog No.:

C1800



Size:

25 ?g



Molecular Weight:

21.4 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~90% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_003341



Image(s):

(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2E1 (UbcH6)







Shipping Method:

Dry ice shipping



References:

1. Nuber U,
et al
. (1996) J Biol Chem 271(5), 2795 – 2800.
2. Yamada HY,
et al
. (2006) Oncogene 25(9), 1330 – 1339. 3. Espinosa A,
et al
. (2008) Exp Cell Res 314, 3605–3613.
4. Espinosa A,
et al
. (2009) J Exp Med 206, 1661–1671.




Details

Ube2E1 is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. Ube2E1 was found to locate in the nucleus. It, along with Ube2D1, is known to complex with the E3 ligase Ro52 to ubiquitinate interferon regulatory transcription factors IRF3 and IRF8. Ube2E1 can also complex with a Ub ligase called RING105 to ubiquitinate a tumor suppressor known as tumor – suppressing subchromosomal transferable fragment
CDN
A (TSSC5).

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2E1 (UbcH6)