商品编号


A3710



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Proteasomes / Activators / Subunits



Size

25 ?g


商品信息

USP
14 is one of the deubiquitinating enzymes of the human 26S proteasome.
USP
14 belongs to the Ub-specific proteases family.
USP
14 catalyzes Ub chain trimming that shortens a polyUb chain from the distal end of the Ub chain.
USP
14 was found to play an essential role in maintaining the protein levels of monomeric Ub in cells. Interestingly,
USP
14 was also found to inhibit proteasomal degradation independent of its deubiquitinating activity.

Additional Information






Product Name:

6xHis-
USP
14



Also Known As:

TGT;
USP
14



Catalog No.:

A3710



Size:

25 ?g



Molecular Weight:

56.1 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~90% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_005151



Image(s):

(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s Lane 2: 5 ?g purified 6xHis-
USP
14







Shipping Method:

Dry ice shipping



References:

1. Lam YA,
et al
. (1997) Nature 385(6618), 737 – 740.
2. Koulich E,
et al
. (2007) Mol Biol Cell, 19(3) 1072 – 1082. 3. Lee BH,
et al
. (2010) Nature 467, 179 – 184.




Details


USP
14 is one of the deubiquitinating enzymes of the human 26S proteasome.
USP
14 belongs to the Ub-specific proteases family.
USP
14 catalyzes Ub chain trimming that shortens a polyUb chain from the distal end of the Ub chain.
USP
14 was found to play an essential role in maintaining the protein levels of monomeric Ub in cells. Interestingly,
USP
14 was also found to inhibit proteasomal degradation independent of its deubiquitinating activity.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s Lane 2: 5 ?g purified 6xHis-
USP
14