商品编号


A3501



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Proteasomes / Activators / Subunits



Size

100 ?g

商品信息

Uch37 is one of the deubiquitinating enzymes of the human 26S proteasome, belongs to the Ub C-terminal hydrolases. Uch37 was found to bind both Adrm1 and S5a subunits of the 26S proteasome. Uch37 likely contributes to the Ub chain trimming activity of the 26S proteasome that shortens a polyUb chain from the distal end of the chain. Currently, how Uch37 is activated on the proteasome is not known.


Additional Information






Product Name:

6xHis-Uch37



Also Known As:

UCHL5;UCH37; CGI-70; INO80R; UCH-L5



Catalog No.:

A3501



Size:

100 ?g



Molecular Weight:

37.6 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~95% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_015984



Image(s):

N/A



Shipping Method:

Dry ice shipping



References:

1. Verma R,
et al
. (2000) Mol Biol Cell 11(10), 3425 – 3439.
2. Koulich E,
et al
. (2007) Mol Biol Cell, 19(3) 1072 – 1082. 3. Husnjak K,
et al
. (2008) Nature 453, 481 – 488.
4. Lee BH,
et al
. (2010) Nature 467, 179 – 184.




Details

Uch37 is one of the deubiquitinating enzymes of the human 26S proteasome, belongs to the Ub C-terminal hydrolases. Uch37 was found to bind both Adrm1 and S5a subunits of the 26S proteasome. Uch37 likely contributes to the Ub chain trimming activity of the 26S proteasome that shortens a polyUb chain from the distal end of the chain. Currently, how Uch37 is activated on the proteasome is not known.