商品编号


A3400



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Proteasomes / Activators / Subunits



Size

25 ?g


商品信息

Adrm1 is an integral Ub receptor of the 26S proteasome. Adrm1 binds both Ub and polyUb chains via its N-terminal Pru domain. The Pru domain also binds S1 to locate Adrm1 on the 26S proteasome. The C-terminal domain of Adrm1 binds the deubiquitinating enzyme Uch37, though which Uch37 is recruited to the 26S proteasome.

Additional Information






Product Name:

6xHis-Adrm1



Also Known As:

ADRM1;ARM1; GP110; Rpn13



Catalog No.:

A3400



Size:

25 ?g



Molecular Weight:

42.2 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~90% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_007002



Image(s):

(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s Lane 2: 5 ?g purified 6xHis-Adrm1







Shipping Method:

Dry ice shipping



References:

1. Verma R,
et al
. (2000) Mol Biol Cell 11(10), 3425 – 3439.
2. Jorgensen JP,
et al
. (2006) J Mol Biol 360(5), 1043 – 1052. 3. Husnjak K,
et al
. (2008) Nature 453, 481 – 488.




Details

Adrm1 is an integral Ub receptor of the 26S proteasome. Adrm1 binds both Ub and polyUb chains via its N-terminal Pru domain. The Pru domain also binds S1 to locate Adrm1 on the 26S proteasome. The C-terminal domain of Adrm1 binds the deubiquitinating enzyme Uch37, though which Uch37 is recruited to the 26S proteasome.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s Lane 2: 5 ?g purified 6xHis-Adrm1