商品编号


A3301



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Proteasomes / Activators / Subunits



Size

100 ?g


商品信息

S5a is one of the integral Ub receptors of the 26S proteasome. It’s N-terminal vWA domain interacts with Rpn9 and Rpn10 on the 26S proteasome. The C-terminal domain of S5a contains two Ub-interacting motifs (UIMs) that bind Ub and Ub chains. S5a prefers to bind polyUb chains; it also binds proteins containing a Ub-like domain. It may directly recognize ubiquitinated proteins or coordinate with other Ub receptors to target substrates for proteasomal degradation.

Additional Information






Product Name:

GST-S5a



Also Known As:

PSMD4;AF; ASF; S5A; AF-1; MCB1; Rpn10; pUB-R5



Catalog No.:

A3301



Size:

100 ?g



Molecular Weight:

40.7 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~95% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_002810



Image(s):

(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s Lane 2: 5 ?g purified GST-S5a







Shipping Method:

Dry ice shipping



References:

1. Deveraux Q,
et al
. (1994) J Biol Chem 269(10), 7059 – 7061.
2. Beal R,
et al
. (1996) Proc Natl Acad Sci 93(2), 861 – 866. 3. Chen L,
et al
. (2002) Mol Cell Biol 22(13), 4902 – 4913.
4. Wang Q,
et al
. (2005) J Mol Biol 348, 727–739.




Details

S5a is one of the integral Ub receptors of the 26S proteasome. It’s N-terminal vWA domain interacts with Rpn9 and Rpn10 on the 26S proteasome. The C-terminal domain of S5a contains two Ub-interacting motifs (UIMs) that bind Ub and Ub chains. S5a prefers to bind polyUb chains; it also binds proteins containing a Ub-like domain. It may directly recognize ubiquitinated proteins or coordinate with other Ub receptors to target substrates for proteasomal degradation.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s Lane 2: 5 ?g purified GST-S5a