商品编号


AG-40T-0534-C250



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

250 ?g

商品信息


More Information



Product Details



Synonyms

Ubiquitin Related Modifier 1; C9orf74



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human URM1 Isoform 1 (Accession Nr. Q9BTM9-1).



Crossreactivity

Human



Formulation

Liquid. In 50mM Hepes pH 7.5, 100mM NaCl, 1mM DTT.



Declaration

Manufactured by Boston Biochem



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Ubiquitin Related Modifier 1 (URM1) is a conserved, ubiquitously expressed cytoplasmic ubiquitin-like protein. It is 101 amino acids (aa) in length with a predicted molecular weight of 11.4 kDa. Human URM1 shares 93% and 94% aa sequence identity with the mouse and rat orthologs, respectively. URM1 contains a core β-grasp fold and a C-terminal glycine-glycine motif characteristic of ubiquitin and ubiquitin-like modifiers. URM1 is activated by the ubiquitin-activating (E1)-like enzyme MOCS3, Uba4 in yeast, via the formation of a thiocarboxylate group at its C-terminus. More specifically, MOCS3 and Uba4 mediate the adenylation and subsequent addition of sulfur to the carboxyl group of the C-terminal glycine residue of URM1. Thiocarboxylated URM1 functions as a sulfur carrier in the thiolation of eukaryotic cytoplasmic transfer RNA. URM1 can also be conjugated to lysine residues of several proteins including yeast Ahp1 and human MOCS3, CTU1, and CTU2. URM1 has been implicated in oxygen stress tolerance and nutrient sensing, invasive growth and budding in yeast.