商品编号


AG-40T-0532-C250



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

250 ?g

商品信息


More Information



Product Details



Synonyms

Ubiquitin-fold Modifier 1; C13orf20



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human UFM1 (Accession Nr. NP_057701) fused to a N-terminal His-tag.



Crossreactivity

Human



Formulation

Liquid. In 50mM Hepes pH 6.5, 100mM NaCl, 10 % glycerol.



Other Product Data


Use:
Typical
in vitro
concentrations for conjugate formation is 10-50μM depending on conditions.



Declaration

Manufactured by Boston Biochem



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Ubiquitin-fold Modifier 1 (UFM1), also known as BM-002, is an 85 amino acid (aa) member of the ubiquitin-like protein family that has a predicted molecular weight of 9.1 kDa. Human and mouse UFM1 share 100% aa sequence identity and are primarily localized in the nucleus, but can also be detected in the cytoplasm and the endoplasmic reticulum (ER). ER localization of UFM1 appears to be dependent on the co-expression of UFBP1. Initially expressed as an inactive precursor, UFM1 undergoes proteolytic cleavage at the C-terminus to expose a conserved glycine residue that is necessary for UFM1 conjugation to target proteins. Conjugation of UFM1 to target proteins requires a UFM1-activating (E1) enzyme, a UFM1-conjugating (E2) enzyme and a UFM1 ligase (E3). UFM1 has been shown to be a mediator of ER stress-induced cancer and to promote the pathogenesis of Leishmania.