商品编号


YIF-LF-P0042



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

0.5 mg

商品信息


More Information



Product Details



Synonyms

UBB; Frameshift



Product Type

Protein



Properties



Source/Host

E. coli



Crossreactivity

Human



Purity

≥95% (SDS-PAGE)



Concentration

1 mg/ml



Formulation

Liquid in 20mM HEPES, pH7.0, 10% Glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Avoid freeze/thaw cycles.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Ubiquitin+1 (Ub+1) is a novel mutant form of ubiquitin that can be produced through a process known as molecular frameshift. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Especially ub+1 is accumulated in aggregates containing amyloid-β and phosphorylated-tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of patients with Alzheimer's disease. Also ub+1 acts as an aggravating factor in polyglutamine-induced neuro-degeneration.


Product References
1) Van Leeuwen, F.W. et al. (1998) Science, 279, 242-247. (General)
2) Van Leeuwen, F.W. et al. (1998) Trends Neurosci. 21(8), 331-335. (General)