商品编号


YIF-LF-P0054



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

0.5 mg

商品信息


More Information



Product Details



Synonyms

TTR; ATTR; PALB; TBPA; Prealbumin; Transthyretin



Product Type

Protein



Properties



Source/Host

E. coli



Crossreactivity

Human



Purity

≥90% (SDS-PAGE)



Formulation

Lyophilized from 20mM HEPES, pH7.0.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

After reconstitution, store at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Transthyretin (TTR) , generally called prealbumin, is a plasma protein that plays an important role in physiology such as a transporter of hormone thyroxine and retinal-binding protein. After produced primarily in the liver, TTR is excreted into the plasma. TTR represents a disproportionate fraction (25%) of CSF protein, prompting the suggestion that it is either selectively transported across the blood-CSF barrier or synthesized de novo within the central nervous system. Transthyretin is a constituent found to the neuritic plaques, neurofibrillary tangles, and microangiopathic lesions of senile cerebral amyloid. It has been reported that more than 40 different mutations in the TTR gene associated with amyloid deposition.


Product References
1) Hamilton, J.A. and Benson, M.D. (2001) Cell. Mol. Life Sci. 58, 1491-1521. (General)
2) Shirahama, T. et al. (1982) Am. J. Path. 107, 41-50. (General)
3) Episkopou, V. et al. (1993) Proc. Nat. Acad. Sci. 90, 2375-2379. (General)
4) Saraiva, M.J.M. (1995) Hum. Mutat. 5, 191-196. (General)
5) Pfeffer, B. et al. (2004) Mol. Vis. 10, 23-30. (General)