商品编号


AG-40A-0059-C050



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

50 ?g


商品信息


More Information



Product Details



Synonyms

Interleukin-1 Receptor-like 1; IL-1 Receptor-like 1; IL1RL1; IL-33 Receptor; Interleukin-33 Receptor



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

Signal peptide and the sequence of isoform 2 of human ST2 (aa 1-328) are fused at the C-terminus to the Fc portion of human IgG1.



Crossreactivity

Human



Specificity

Binds to human IL-33.



BIOLOG
ical Activity

Interacts with human IL-33.



MW

~90kDa (SDS-PAGE)



Purity

≥90% (SDS-PAGE)



Endotoxin Content

<0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.1eu>



Concentration

~0.5mg/ml



Formulation

Liquid. 0.2μm-filtered solution in PBS, pH 7.2.



Other Product Data

UniProt link Q01638: ST2 (human) [Precursor]



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
For maximum product recovery after thawing, centrifuge the vial before opening the cap.



Use/St
ABI
lity

Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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The ST2 (Interleukin-1 receptor-like 1; Interleukin-33 receptor) gene was originally identified as a gene induced by serum or oncogene expression in fibroblasts. The gene produces a shorter soluble secreted form (ST2) and a longer, transmembrane form (ST2L) by alternative splicing. Soluble ST2 has been shown to downregulate the expression of TLR1 and TLR4. ST2L negatively regulates TLR4 signaling and induces endotoxin tolerance, and enhances Th2 responses. IL-33 is the specific ligand for ST2L.