商品编号


AG-40A-0093T-C010



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Toll/Interleukin-1 Receptor 8; TIR8; Single Ig IL-1R-related Molecule



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1.



Crossreactivity

Human



MW

~50kDa (SDS-PAGE)



Purity

≥90% (SDS-PAGE)



Endotoxin Content

<0.06eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.06eu>



Concentration

After reconstitution:
for 10?g size:
0.1mg/ml
for 50?g size:
1 mg/ml



Reconstitution


10?g size:
Reconstitute with 100?l sterile water.
50?g size:
Reconstitute with 50?l sterile water.



Accession Number

AAH03591.1



Formulation

Lyophilized from 0.2μm-filtered solution in PBS.



Other Product Data

NCBI link AAH03591.1: SIGIRR (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.