商品编号


AG-40B-0123-3010



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

3 x 10 ?g


商品信息


More Information



Product Details



Synonyms

Pyrin Domain-containing Protein 1; PAAD-only Protein 1; Pyrin-only Protein 1; PYC1



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human POP1 (aa 2-89) is fused at the N-terminus to a GST tag.



Crossreactivity

Human



MW

~38 kDa



Purity

≥95% (SDS-PAGE)



Concentration

0.1mg/ml after reconstitution.



Reconstitution

Reconstitute with 100μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

Uni-Prot link Q8WXC3?: POP1




Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1β and IL-18. Members of the Nod-like receptor family (NLRs), including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). Pyrin domain-containing protein 1 (POP1) interacts with the protein Asc (Pycard) and modulates the interaction of Asc to NLR proteins.