商品编号


AG-40T-0047-C005



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

5 ?g


商品信息


More Information



Product Details



Synonyms

Placenta Growth Factor; PLGF-1; PLGF-131



Product Type

Protein



Properties



Source/Host

Sf9 cells



Sequence

Human PLGF (131aa).



Crossreactivity

Human



BIOLOG
ical Activity

Measured by its
ABI
lity to bind to immobilized rhsFlt-1 in a functional
ELISA
. Recombinant human PLGF can bind to immobilized rhsFlt-1 (100ng/well) with a linear range at 0.5-10ng/ml.



MW

~34kDa (dimer)



Purity

≥95% (SDS-PAGE)



Reconstitution

Reconstitute with 50mM acetic acid or PBS/water. This solution can be diluted into other buffered solutions or stored frozen for future use.



Formulation

Lyophilized.



Other Product Data

UniProt link P49763: PLGF (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Human placenta growth factor-1 (PLGF-1; PLGF) binds to the receptor FLT1/VEGFR-1. It acts as a potent chemoattractant for monocytes and only as a very weak mitogen for some endothelial cell types. The physiological function
in vivo
is still controversial. In several reports it was shown not to be a potent mitogen for endothelial cells and not angiogenic
in vivo
by using different assays. It was shown that PLGF from cell culture supernatants was angiogenic in the CAM assay and in the rabbit cornea assay.


Product References
Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis: S. Ahmad, et al.; Vasc. Cell
3
, 2011