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Adipogen/IL-33 (human) (rec.) (untagged)/AG-40B-0038-C010/10 ?g

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Adipogen/IL-33 (human) (rec.) (untagged)/AG-40B-0038-C010/10 ?g


商品编号


AG-40B-0038-C010



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Interleukin-33; IL-1F11; NF-HEV



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human IL-33 (aa 112-270) is untagged.



Crossreactivity

Human
Mouse



Specificity

Binds to human and mouse ST2.



BIOLOG
ical Activity

Activates human and mouse ST2-dependent NF-κB pathway.



MW

~18kDa



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

0.1mg/ml after reconstitution.



Reconstitution

Reconstitute with 100μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

UniProt link Q2YEJ5: Interleukin-33 (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The
ABI
lity of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.


Product References

An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor: M. Suzukawa, et al.; J. Immunol.
181,
5981 (2008)

Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils: M. Suzukawa, et al.; J. Immunol.
186,
5254 (2011)


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产品货号:1356.0

1356.0 ¥
11至15个工作日送达