商品编号


AG-40T-0271-C050



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

50 ?g

商品信息


More Information



Product Details



Synonyms

Heat Shock 40 kDa Protein; Hdj1; HSPF1; DNAJ1; DNAJB1



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human HSP40 (Accession Nr. Q6FHS4) fused to a C-terminal His-tag.



Crossreactivity

Human



Formulation

Liquid. In 50mM Hepes pH 7.5, 100mM NaCl, 1mM TCEP.



Other Product Data


Use:
Typical enzyme concentration for use
in vitro
is dependent on specific application.



Declaration

Manufactured by Boston Biochem



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Heat shock protein 40 (HSP40, also known as DNAJB1) is the human homologue of the bacterial DnaJ heat shock protein. Heat shock proteins (HSPs) are a highly conserved family of stress response proteins. HSPs function primarily as molecular chaperones, facilitating the folding of other cellular proteins, preventing protein aggregation, or targeting improperly folded proteins to specific degradative pathways. Heat Shock Proteins are ubiquitously expressed in all organisms, and they are induced in response to various types of environmental stresses like heat, cold, and oxygen deprivation. HSP40 is a stress induc
IBL
e chaperone that colocalizes with HSP70 and can bind unfolded proteins and prevent protein denaturation and aggregation. The conserved amino terminal J domain can interact with HSP70 and stimulate its ATPase activity. HSP40 and HSP70 are required to target some misfolded proteins to the ubiquitin E3 ligase CHIP (Stub1) for subsequent ubiquitination.