商品编号


AG-40B-0178-3050



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

3 x 50 ?g

商品信息


More Information



Product Details



Synonyms

Heligmosomoides Polygyrus Alarmin Release Inhibitor



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence


Heligmosomoides polygyrus
protein HpARI (aa 17-251) is fused at the C-terminus to a His-tag.




Crossreactivity

Human
Mouse



Specificity


Binds to human and mouse IL-33.




MW

~40kDa



Purity

≥90% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

After reconstitution: 1mg/ml



Reconstitution

Reconstitute with 50μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data


Worm base HPBE_0000813301: Heligmosomoides polygyrus protein HpARI




Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





HpARI is a protein secreted by the mouse parasite
Heligmosomoides polygyrus
. The mature protein HpARI, containing three predicted Complement Control Protein (CCP)-like modules (also known as Short Consensus Repeats (SCRs) or sushi-domains), suppresses type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. During cell damage, HpARI gains access to the nucleus of necrotic cells, where it binds directly to IL-33 and nuclear DNA, preventing secretion and binding of IL-33 to its receptor. HpARI is a new type of reagent to prevent IL-33-mediated pathology.


Product References

HpARI protein secreted by a helminth parasite suppresses interleukin-33: M. Osbourne, et al.; Immunity
47,
739 (2017)