商品编号


L0251-5 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

5 mg

商品信息

Product ID
L0251
Cas No.
110590-60-8
Purity
≥98%
Description
Product Info
Shipping and Storage
Downloads
References

Description
This nonapeptide is equivalent to a sequence found on the B1 chain of laminin (925-933); it exhibits vasoconstrictive, anti-metastatic, and anti-angiogenic activities. This peptide increases vascular tone, producing vasoconstriction and inducing Ca2+ influx in vascular smooth muscle cells; it also activates nonselective cation channels. In vitro, this peptide inhibits angiogenesis and cell migration. In vivo, this peptide inhibits growth of sarcoma 180 tumors and Lewis lung carcinoma tumors. Like other laminin peptides, this sequence can be used in combination with chemotherapeutics to deliver the drug to target tumor tissues.
Product Info
Cas No.
110590-60-8
Purity
≥98%
Formula
C
40
H
62
N
12
O
14
S
Formula Wt.
967.06
IUPAC Name
L-Cysteinyl-L-α-aspartyl-L-prolylglycyl-L-tyrosyl-L-isoleucylglycyl-L-seryl-N5-(diaminomethylene)-L-ornithine
Synonym
Laminin (925-933)
Appearance
White to off white powder
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
L0251 Info Sheet PDF
References
Wenzel D, Koch M, Matthey M, et al. Identification of a novel vasoconstrictor peptide specific for the systemic circulation. Hypertension. 2012 Jun;59(6):1256-62. PMID: 22547445.
Sakamoto N, Iwahana M, Tanaka NG, et al. Inhibition of angiogenesis and tumor growth by a synthetic laminin peptide, CDPGYIGSR-NH2. Cancer Res. 1991 Feb 1;51(3):903-6. PMID: 1703042.