商品编号


G5772-1 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

1 mg

商品信息

Product ID
G5772
Cas No.
145781-92-6
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Goserelin acts as a peptide ago
NIST
at the gonadotropin-releasing hormone (GnRH) or luteinizing hormone releasing hormone (LHRH) receptor, stimulating release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and decreasing androgen levels. Goserelin exhibits anticancer chemotherapeutic benefit, inhibiting cell proliferation and tumor growth in cellular and animal models of prostate cancer, likely through indirect activation of PKC and inhibition of EGFR activity. Goserelin also inhibits cell proliferation and tumor growth in cellular and animal models of ovarian cancer through a mechanism that involves inhibition of Akt phosphorylation. In other animal models, goserelin increases bone elongation.
Product Info
Cas No.
145781-92-6
Purity
≥95%
Formula
C
59
H
84
N
18
O
14
C
2
H
4
O
2
Formula Wt.
1329.48
IUPAC Name
acetic acid;N-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Appearance
White to off white powder
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
G5772 Info Sheet PDF
Brochures
PI3K-Akt-mTORC Pathway Booklet
References
Detti L, Uhlmann RA, Zhang J, et al. Goserelin fosters bone elongation but does not prevent ovarian damage in cyclophosphamide-treated prepubertal mice. Fertil Steril. 2014 Jan 23. pii: S0015-0282(13)03460-2. [Epub ahead of print]. PMID: 24462062.
Zhang Y, Ding JX, Tao X, et al. Goserelin can inhibit ovarian cancer proliferation and simultaneously protect ovarian function from cisplatin: an in vitro and in vivo study. J Chemother. 2013 Apr;25(2):96-103. PMID: 23684357.
Wells A, Souto JC, Solava J, et al. Luteinizing hormone-releasing hormone ago
NIST
limits DU-145 prostate cancer growth by attenuating epidermal growth factor receptor signaling. Clin Cancer Res. 2002 Apr;8(4):1251-7. PMID: 11948140.