商品编号


P0352-0.5 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

0.5 mg

商品信息

Product ID
P0352
Cas No.
Purity
≥98%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Pancreastatin is an endogenous peptide derived from chromogranin-A that regulates insulin action, inhibiting insulin secretion and increasing glucagon secretion. Pancreastatin binds and inhibits GRP78, decreasing insulin-stimulated glucose uptake and expression of G6Pase. This peptide displays pro-diabetic activity and induces glycogenolysis and lipolysis. Pancreastatin is also used as a bio
Marker
to detect neuroendocrine tumors and shows some correlation with diabetes and hypertension.
Product Info
Purity
≥98%
Formula
C
214
H
330
N
68
O
76
S
Formula Wt.
5103.4
Synonym
PST
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
P0352 Info Sheet PDF
References
Biswas N, Friese RS, Gayen JR, et al. Discovery of a novel target for the dysglycemic chromogranin A fragment pancreastatin: interaction with the chaperone GRP78 to influence metabolism. PLoS One. 2014 Jan 20;9(1):e84132. PMID: 24465394.
Rustagi S, Warner RR, Divino CM. Serum pancreastatin: the next predictive neuroendocrine tumor
Marker
. J Surg Oncol. 2013 Aug;108(2):126-8. PMID: 23775817.
Sánchez-Margalet V, González-Yanes C, Najib S, et al. Metabolic effects and mechanism of action of the chromogranin A-derived peptide pancreastatin. Regul Pept. 2010 Apr 9;161(1-3):8-14. PMID: 20184923.