商品编号


N5210-1 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

1 mg

商品信息

Product ID
N5210
Cas No.
170713-75-4
Purity
≥98%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Nociceptin is an endogenous neuropeptide that binds the nociceptin (NOP) receptor, considered the ‘fourth’ opioid receptor subtype. Nociceptin displays anti-opioid activity, modulating nociception and exhibiting anti-analgesic properties in vivo. In the amygdala, nociceptin displays neuromodulatory activity, decreasing glutamate release. Additionally, nociceptin inhibits the activity of POMC neurons and modulates GIRK channel signaling, altering animal mating behavior.
Product Info
Cas No.
170713-75-4
Purity
≥98%
Formula
C
79
H
129
N
27
O
22
Formula Wt.
1809.1
Chemical Name
Orphanin FQ
Solubility
Soluble in water.
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
N5210 Info Sheet PDF
References
Borgquist A, Rivas VM, Kachani M, et al. Gonadal Steroids Differentially Modulate the Actions of Orphanin FQ/Nociceptin at A Physiologically Relevant Circuit Controlling Female Sexual Receptivity. J Neuroendocrinol. 2014 May;26(5):329-40. PMID: 24617903.
Kallupi M, Varodayan FP, Oleata CS, et al. Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Neuropsychopharmacology. 2014 Apr;39(5):1081-92. PMID: 24169802.
Okuda-Ashitaka E, Minami T, Tachibana S, et al. Nocistatin, a peptide that blocks nociceptin action in pain transmission. Nature. 1998 Mar 19;392(6673):286-9. PMID: 9521323.