商品编号


F3207-5 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

5 mg

商品信息

Product ID
F3207
Cas No.
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Fibronectin CS-1 peptide binds α4β1 integrin; it exhibits pro-metastatic and immunomodulatory activities. Fibronectin CS-1 peptide is involved in oral squamous cell carcinoma pathogenesis, regulating migration and invasion. This peptide may increase expression of matrix metalloproteinases (MMPs). In vitro, fibronectin CS-1 peptide stimulates proliferation of T cells. In animal models of cerebral ischemia/reperfusion, fibronectin CS-1 peptide decreases leukocyte infiltration in lesioned areas, decreasing infarct size.
Product Info
Purity
≥95%
Formula
C
38
H
64
N
8
O
15
Formula Wt.
872.97
Synonym
Fibronectin CS1
Solubility
Soluble in water.
Appearance
White to off-white powder
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
F3207 Info Sheet PDF
References
Kamarajan P, Garcia-Pardo A, D'Silva NJ, et al. The CS1 segment of fibronectin is involved in human OSCC pathogenesis by mediating OSCC cell spre
ADI
ng, migration, and invasion. BMC Cancer. 2010 Jun 25;10:330. PMID: 20579373.
Yakubenko VP, Lobb RR, Plow EF, et al. Differential induction of gelatinase B (MMP-9) and gelatinase A (MMP-2) in T lymphocytes upon alpha(4)beta(1)-mediated adhesion to VCAM-1 and the CS-1 peptide of fibronectin. Exp Cell Res. 2000 Oct 10;260(1):73-84. PMID: 11010812.
Lehnert K, Print CG, Yang Y, et al. MAdCAM-1 costimulates T cell proliferation exclusively through integrin alpha4beta7, whereas VCAM-1 and CS-1 peptide use alpha4beta1: evidence for "remote" costimulation and induction of hyperresponsiveness to B7 molecules. Eur J Immunol. 1998 Nov;28(11):3605-15. PMID: 9842903.
Yanaka K, Camarata PJ, Spellman SR, et al. Neuronal protection from cerebral ischemia by synthetic fibronectin peptides to leukocyte adhesion molecules. J Cereb Blood Flow Metab. 1996 Nov;16(6):1120-5. PMID: 8898683.