商品编号


E5222-1 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

1 mg

商品信息

Product ID
E5222
Cas No.
117399-93-6
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Endothelin-3 is an endogenous peptide ago
NIST
at endothelin B (ET-B) receptors that exhibits anti-inflammatory, neuromodulatory, and pro-angiogenic activities. In animal models, endothelin-3 inhibits platelet-activating factor-induced edema. In other models, this peptide decreases tyrosine hydroxylase activity in an NO/cGMP/PKG-dependent manner, suppressing hypothalamic release of norepinephrine. In vitro, endothelin-3 activates ET-B receptors, increasing expression of VEGF, COX1/2, HIF-1α, and PGE2.
Product Info
Cas No.
117399-93-6
Purity
≥95%
Formula
C
121
H
168
N
26
O
33
S
4
Formula Wt.
2643.1
Synonym
Rat endothelin-3
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
MSD
S
E5222
MSD
S PDF
Info Sheet
E5222 Info Sheet PDF
References
Sato A, Ebina K. Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. Inflamm Res. 2013 Apr;62(4):417-24. PMID: 23370722.
Spinella F, Rosanò L, Di Castro V, et al. Endothelin-1 and endothelin-3 promote invasive behavior via hypoxia-induc
IBL
e factor-1alpha in human melanoma cells. Cancer Res. 2007 Feb 15;67(4):1725-34. PMID: 17308114.
Morgazo C, Perfume G, Legaz G, et al. Involvement of nitric oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins 1 and 3 in the rat anterior hypothalamus. Biochem Biophys Res Commun. 2005 Sep 2;334(3):796-802. PMID: 16023617.