商品编号


E5221-2.5 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

2.5 mg

商品信息

Product ID
E5221
Cas No.
123562-20-9
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Endothelin-2 is an endogenous peptide ago
NIST
at endothelin A and B (ET-A/B) receptors that exhibits anti-angiogenic and vasoconstrictive activities. Endothelin-2 inhibits endothelial cell migration and invasion, suppressing vascular development in the retina. In arteries, this peptide induces vasoconstriction in a PLC/ROCK-dependent manner. Additionally, endothelin-2 promotes myelination in animal models.
Product Info
Cas No.
123562-20-9
Purity
≥95%
Formula
C
115
H
160
N
26
O
32
S
4
Formula Wt.
2546.97
Appearance
White to off white powder
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
MSD
S
E5221
MSD
S PDF
Info Sheet
E5221 Info Sheet PDF
References
Compeer MG, Janssen GM, De Mey JG. Endothelin-1 and endothelin-2 initiate and maintain contractile responses by different mechanisms in rat mesenteric and cerebral arteries. Br J Pharmacol. 2013 Nov;170(6):1199-209. PMID: 23941276.
Rattner A, Yu H, Williams J, et al. Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3830-9. PMID: 24043815.
Yuen TJ, Johnson KR, Miron VE, et al. Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination. Brain. 2013 Apr;136(Pt 4):1035-47. PMID: 23518706.