商品编号


C9614-5 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

5 mg

商品信息

Product ID
C9614
Cas No.
83602-39-5
Purity
≥96%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Cyclosporin H is a cyclosporin metabolite that inhibits the formyl peptide receptor but not calmodulin. Cyclosporin H lacks immunosuppressive activity but inhibits basophil activation.
Product Info
Cas No.
83602-39-5
Purity
≥96%
Formula
C
62
H
111
N
11
O
12
Formula Wt.
1202.61
IUPAC Name
(3S,6S,9S,12R,15S,18S,21R,24S,30S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,22,25,28-decamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Synonym
Csh cyclosporin; Cyclosporine H
Melting Point
162-167°C
Solubility
Soluble in DMSO, ethanol, Acetone, chloroform.
Appearance
White Crystalline Powder
Shipping and Storage
Store Temp
Ambient
Ship Temp
Ambient
Downloads
MSD
S
C9614
MSD
S PDF
Info Sheet
C9614 Info Sheet PDF
References
Stenfeldt AL, Karlsson J, Wenner?s C, et al. Cyclosporin H, Boc-MLF and Boc-FLFLF are antago
NIST
s that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation. 2007 Dec;30(6):224-9. PMID: 17687636.
Yan P, Nanamori M, Sun M, et al. The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J Immunol. 2006 Nov 15;177(10):7050-8. PMID: 17082621.
de Paulis A, Ciccarelli A, de Crescenzo G, et al. Cyclosporin H is a potent and selective competitive antago
NIST
of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. J Allergy Clin Immunol. 1996 Jul;98(1):152-64. PMID: 8765829.