商品编号


C9611-1 g



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

1 g

商品信息

Product ID
C9611
Cas No.
59865-13-3
Purity
≥98%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Cyclosporin A is a cyclic peptide that exhibits immunosuppressive activity. Cyclosporin A is clinically used to prevent rejection in organ transplants and to treat or prevent graft-versus-host disease (GvHD). Cyclosporin A binds cyclophilin, inhibiting calcineurin and decreasing levels of IL-2 and activated T cells. Cyclosporin A also shows benefit in the treatment of traumatic brain injury.
Product Info
Cas No.
59865-13-3
Purity
≥98%
Formula
C
62
H
111
N
11
O
12
Formula Wt.
1202.61
IUPAC Name
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Synonym
Cyclosporine; Ciclosporin; Sandimmun; Neoral
Melting Point
148-151°C
Solubility
Soluble in methanol, ethanol, acetone, ether or chloroform. Very slightly soluble in water.
Appearance
White Crystal Powder
Shipping and Storage
Store Temp
Ambient
Ship Temp
Ambient
Downloads
MSD
S
C9611
MSD
S PDF
Info Sheet
C9611 Info Sheet PDF
References
Lulic D, Burns J, Bae EC, et al. A review of laboratory and clinical data supporting the safety and efficacy of cyclosporin A in traumatic brain injury. Neurosurgery. 2011 May;68(5):1172-86. PMID: 21307793.
Reynolds NJ, Al-Daraji WI. Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology. Clin Exp Dermatol. 2002 Oct;27(7):555-61. PMID: 12464150.
Handschumacher RE, Harding MW, Rice J, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7. PMID: 6238408.
Koseki N, Deguchi J, Yamashita A, et al. Establishment fo a novel experimental protocol for drug-induced seizure li
ABI
lity screening based on a locomotor activity assay in zebrafish. J Toxicol Sci. 2014 Aug;39(4):579-600. PMID: 25056783.