商品编号


S1969-10 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

10 mg

商品信息

Product ID
S1969
Cas No.
86168-78-7
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Sermorelin is a synthetic 28-amino acid peptide analog of growth hormone-releasing hormone (GHRH). Sermorelin exhibits immunomodulatory and pro-angiogenic activities. In vivo, sermorelin stimulates secretion of growth hormone from the pituitary gland; it also increases IGF-1 secretion and increases the number of activated immune cells in circulation. Sermorelin induces histamine release from mast cells in a Ca2+-dependent manner. Additionally, this peptide increases secretion of VEGF and chromogranin A, increasing proliferation in neuroendocrine tumor cells.
Product Info
Cas No.
86168-78-7
Purity
≥95%
Formula
C
149
H
246
N
44
O
42
S
Formula Wt.
3358.03
Synonym
GHRH(1-29)NH2, human
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
S1969 Info Sheet PDF
References
Stepień T, Sacewicz M, Lawnicka H, et al. Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitro. Neuropeptides. 2009 Oct;43(5):397-400. PMID: 19747727.
Khorram O, Yeung M, Vu L, et al. Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 admi
NIST
ration on the immune system of aging men and women. J Clin Endocrinol Metab. 1997 Nov;82(11):3590-6. PMID: 9360512.
Estévez MD, Alfonso A, Vieytes MR, et al. Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release. Inflamm Res. 1995 Feb;44(2):87-91. PMID: 7544679.
Sato M, Chihara K, Kita T, et al. Physiological role of somatostatin-mediated autofeedback regulation for growth hormone: importance of growth hormone in triggering somatostatin release during a trough period of pulsatile growth hormone release in conscious male rats. Neuroendocrinology. 1989 Aug;50(2):139-51. PMID: 2571099.