商品编号


U6956-2.5 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

2.5 mg

商品信息

Product ID
U6956
Cas No.
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Uroguanylin is an endogenous natriuretic peptide that modulates activity through Na+/H+ exchangers in intestinal and renal tissues, altering electrolyte and water transport. Uroguanylin activates guanylyl cyclase receptors to increase cGMP production. Uroguanylin also increases activity of Cl- channels. Uroguanylin inhibits bicarbonate reabsorption and increases net water secretion through signaling cascades mediated by PKA and PKG.
Product Info
Purity
≥95%
Formula
C
64
H
102
N
18
O
26
S
4
Formula Wt.
1667.89
Appearance
White to off white powder
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
U6956 Info Sheet PDF
References
Teixeira MD, Nascimento NR, Fonteles MC, et al. Uroguanylin induces electroencephalographic spikes in rats. Braz J Biol. 2013 Aug;73(3):623-7. PMID: 24212704.
Lessa LM, Carraro-Lacroix LR, Crajoinas RO, et al. Mechanisms underlying the inhibitory effects of uroguanylin on NHE3 transport activity in renal proximal tubule. Am J Physiol Renal Physiol. 2012 Nov 15;303(10):F1399-408. PMID: 22952280.
Toriano R, Ozu M, Politi MT, et al. Uroguanylin regulates net fluid secretion via the NHE2 isoform of the Na/H+ exchanger in an intestinal cellular model. Cell Physiol Biochem. 2011;28(4):733-42. PMID: 22178885.