商品编号


U6118-1 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

1 mg

商品信息

Product ID
U6118
Cas No.
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Uperolein is a physalaemin-like endecapeptide that acts as a tachykinin, binding the neurokinin-1 (NK1) receptor. Uperolein induces spasmogenic activity in smooth muscle cells in the stomach. Uperolein was initially found in the skin of species of Uperoleia and Taudactylus frogs.
Product Info
Purity
≥95%
Formula
C
57
H
79
N
13
O
16
S
Formula Wt.
1234.42
IUPAC Name
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]-2-[[(2S)-1-[(2S)-3-hydroxy-2-[[(2S)-1-[(2S)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]butanediamide
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
U6118 Info Sheet PDF
References
Dike A, Cowsik SM. Solution structure of amphibian tachykinin Uperolein bound to DPC micelles. J Struct Biol. 2006 Dec;156(3):442-52. PMID: 16979908.
Bertaccini G, Coruzzi G. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163-6. PMID: 882154.
Erspamer V, Negri L, Erspamer GF, et al. Uperolein and other active peptides in the skin of the Australian leptodactylid frogs Uperoleia and Taudactylus. Naunyn Schmiedebergs Arch Pharmacol. 1975;289(1):41-54. PMID: 1186916.