商品编号


T8020-10 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

10 mg

商品信息

Product ID
T8020
Cas No.
9063-57-4
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Tuftsin is a tetrapeptide that binds the neuropilin-1 (Nrp1) receptor, modulating TGF-β, cGMP, and Ca2+ signaling. Tuftsin is derived from the Fc region of IgG. Tuftsin exhibits immunomodulatory activity, inducing leukocytes to become cytotoxic effector cells and stimulating phagocytosis in macrophages and microglia in cellular models. Tuftsin also displays anticancer chemotherapeutic benefit, enhancing the effects of co-admi
NIST
ered chemotherapeutic compounds. In animal models, tuftsin also inhibits withdrawal-associated behaviors.
Product Info
Cas No.
9063-57-4
Purity
≥95%
Formula
C
21
H
40
N
8
O
6
Formula Wt.
500.6
IUPAC Name
(2S)-2-[[(2S)-1-[6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Appearance
White to off white powder
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
MSD
S
T8020
MSD
S PDF
Info Sheet
T8020 Info Sheet PDF
References
Nissen JC, Selwood DL, Tsirka SE. Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J Neu
Roche
m. 2013 Nov;127(3):394-402. PMID: 24033337.
Aronowski J, Wleklik M, Gumulka SW, et al. Modification of morphine withdrawal: effect of tuftsin, [Lys4]-tuftsinyltuftsin, tetrapeptide fragment (1-4) of substance P and its amide. Life Sci. 1985 Oct 28;37(17):1649-53. PMID: 2414628.
Nishioka K, Babcock GF, Phillips JH, et al. Antitumor effect of tuftsin. Mol Cell Biochem. 1981 Dec 4;41:13-8. PMID: 6895773.
St
ABI
nsky Y, Bar-Shavit Z, Fridkin M, et al. On the mechanism of action of the phagocytosis-stimulating peptide tuftsin. Mol Cell Biochem. 1980 Apr 18;30(2):71-7. PMID: 6247642.