商品编号


T7037-100 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

100 mg

商品信息

Product ID
T7037
Cas No.
140194-24-7
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Triptorelin is an analog of gonadotropin-releasing hormone I (GnRH-I); it is a decapeptide that activates the GnRH receptor in the pituitary gland, decreasing secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Triptorelin inhibits production of cAMP in a Ca2+- and PKC-dependent manner. Triptorelin exhibits anxiolytic and potentially anticancer activities. In vitro, triptorelin’s modulation of autocrine regulatory signaling may induce cell cycle arrest.
Product Info
Cas No.
140194-24-7
Purity
≥95%
Formula
C
64
H
82
N
18
O
13
? C
2
H
4
O
2
Formula Wt.
1371.52
IUPAC Name
acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Appearance
White Powder
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
T7037 Info Sheet PDF
References
Saleh-Abady MM, Alizadeh A, Shamsipour F, et al. The anticancer activity compared between triptorelin and a new gonadotropin releasing hormone analogue. Avicenna J Med Biotechnol. 2009 Jul;1(2):105-10. PMID: 23407883.
Larivière S, Garrel-Lazayres G, Simon V, et al. Gonadotropin-releasing hormone inhibits pituitary adenylyl cyclase-activating polypeptide coupling to 3',5'-cyclic adenosine-5'-monophosphate pathway in LbetaT2 gonadotrope cells through novel protein kinase C isoforms and phosphorylation of pituitary adenylyl cyclase-activating polypeptide type I receptor. Endocrinology. 2008 Dec;149(12):6389-98. PMID: 18755795.
Umathe SN, Bhutada PS, Jain NS, et al. Effects of central admi
NIST
ration of gonadotropin-releasing hormone ago
NIST
s and antago
NIST
on elevated plus-maze and social interaction behavior in rats. Behav Pharmacol. 2008 Jul;19(4):308-16. PMID: 18622178.
Kim JW, Lee YS, Kim BK, et al. Cell cycle arrest in endometrial carcinoma cells exposed to gonadotropin-releasing hormone analog. Gynecol Oncol. 1999 Jun;73(3):368-71. PMID: 10366462.