商品编号


T0077-1 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

1 mg

商品信息

Product ID
T0077
Cas No.
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Transactivator of transcription (TAT) protein is produced by HIV-1 and is involved in the induction of HIV-associated neurologic disorders (HAND). TAT is a neurotoxin that infects neurons, which HIV is unable to do. In neurons, TAT increases the number of inhibitory synapses and decreases the number of excitatory synapses in a Ca2+-dependent manner. TAT also activates microglia and other myeloid cells, disrupting cytokine/chemokine homeostasis and inducing neuroinflammation. This peptide sequence (YGRKKRRQRRRGYGRKKRRQRRRG) represents two back-to-back protein transduction (cell-penetrating) domains of TAT.
Product Info
Purity
≥95%
Formula
C
132
H
240
N
66
O
29
Formula Wt.
3215.81
Synonym
TAT 2-4, TAT peptide, YGRKKRRQRRRGYGRKKRRQRRRG
Appearance
White to off white powder
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
T0077 Info Sheet PDF
References
Hargus NJ, Thayer SA. Human immunodeficiency virus-1 Tat protein increases the number of inhibitory synapses between hippocampal neurons in culture. J Neurosci. 2013 Nov 6;33(45):17908-20. PMID: 24198379.
Bethel-Brown C, Yao H, Callen S, et al. HIV-1 Tat-mediated induction of platelet-derived growth factor in astrocytes: role of early growth response gene 1. J Immunol. 2011 Apr 1;186(7):4119-29. PMID: 21368226.
Lu SM, Tremblay M?, King IL, et al. HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells. PLoS One. 2011;6(9):e23915. PMID: 21912650.