商品编号


A5280-5 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

5 mg

商品信息

Product ID
A5280
Cas No.
23025-68-5
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Angiotensin II (AT II) is a peptide produced from AT I by angiotensin-converting-enzyme (ACE). AT II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels; this results in contraction and vasoconstriction, increasing blood pressure. AT II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney. Here, AT II increases reabsorption of Na+ and HCO3- and excretion of H+, increasing blood volume and pH and further increasing blood pressure.
Product Info
Cas No.
23025-68-5
Purity
≥95%
Formula
C
40
H
54
N
8
O
8
Formula Wt.
774.93
IUPAC Name
2-[[1-[2-[[2-[[2-[(2-amino-3-methylbutanoyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
Appearance
White to Off-white Powder
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
A5280 Info Sheet PDF
References
De Giusti VC, Ciancio MC, Orlowski A, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411. PMID: 24478712.
Moon JY. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-45. PMID: 24627703.