商品编号


dendritic-cells



品牌


MatTek



公司


MatTek Corporation



公司分类


Primary Cells & Media



Size

1 Ea


商品信息

Dendritic cells (DC) play a key role in the immunological reactions throughout the body. DC are highly specialized antigen-presenting cells (APC) located in the skin, mucosa, and lymphoid tissues. DC play a key role in the induction phase of contact allergenicity, and can be used in vitro to study?contact sensitization and other immunological reactions of the body
.

Autotologous T Cells (TC-100-CRY & TC-100-RT) are available upon request.

?

Product Description:


MatTek
’s DCs are generated from CD34+
Progen
itor cells harvested from umbilical cord blood. ?The proprietary method used generates a large number of cells from each individual donor, allowing for multiple experiments in which the cell origin and functionality are constant. ?
MatTek
’s DCs express CD1a and HLA-DR and can be maintained in culture for at least 14 days without any significant changes in surface
Marker
expression or functionality when cultured with DC-MM according to
MatTek
’s DC Culturing Protocol.

MatTek
’s DCs were analyzed using transmission electron microscopy which show the presence of Birbeck granules, a key ultrastructural
Marker
s of DCs and LCs. ?Upon stimulation with LPS and PMA, a reproduc
IBL
e and significant induction is observed for IL-12, MIP-1α, MIP-3α and TNFα at the gene and protein expression levels. ?Fur
Thermo
re,
MatTek
’s DCs are infectable with HIV and stimulate heterologous T Cells (TC) and autologous TCs following exposure to antigen.

Human Dendritic Cells, 10x


Specifications:



All cells are negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C are not detected by PCR for all donors and cell lots. ?
This product is for research use only.? Not for use in animals, humans or diagnostic purposes.?